Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50043740
Substrate
n/a
Meas. Tech.
ChEMBL_49501 (CHEMBL662796)
IC50
350±n/a nM
Citation
Bird, J; De Mello, RC; Harper, GP; Hunter, DJ; Karran, EH; Markwell, RE; Miles-Williams, AJ; Rahman, SS; Ward, RW Synthesis of novel N-phosphonoalkyl dipeptide inhibitors of human collagenase. J Med Chem 37:158-69 (1994) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50043740
Synonyms:
(S)-4-Benzyloxycarbonylamino-2-{(S)-1-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butylamino}-butyric acid | CHEMBL298443
Type:
Small organic molecule
Emp. Form.:
C29H40N4O7
Mol. Mass.:
556.6505
SMILES:
CNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](CC(C)C)N[C@@H](CCNC(=O)OCc1ccccc1)C(O)=O