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Target
Nicotinamide N-methyltransferase
Ligand
BDBM50502448
Substrate
n/a
Meas. Tech.
ChEMBL_1807605 (CHEMBL4306964)
IC50
>250000±n/a nM
Citation
 Gao, Y; van Haren, MJ; Moret, EE; Rood, JJM; Sartini, D; Salvucci, A; Emanuelli, M; Craveur, P; Babault, N; Jin, J; Martin, NI Bisubstrate Inhibitors of Nicotinamide  J Med Chem 62:6597-6614 (2019) [PubMed]  Article 
Target
Name:
Nicotinamide N-methyltransferase
Synonyms:
NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT)
Type:
Protein
Mol. Mass.:
29571.16
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
264
Sequence:
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
  
Inhibitor
Name:
BDBM50502448
Synonyms:
CHEMBL4554572
Type:
Small organic molecule
Emp. Form.:
C23H29N7O6
Mol. Mass.:
499.5197
SMILES:
NC(=O)CCCCN(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)Cc1cccc(c1)C(O)=O |r|
Structure:
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