Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50505196
Substrate
n/a
Meas. Tech.
ChEMBL_1821757 (CHEMBL4321417)
IC50
1200±n/a nM
Citation
 Otrubova, K; Chatterjee, S; Ghimire, S; Cravatt, BF; Boger, DL N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorg Med Chem 27:1693-1703 (2019) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM50505196
Synonyms:
CHEMBL4459440
Type:
Small organic molecule
Emp. Form.:
C23H28N4O2
Mol. Mass.:
392.494
SMILES:
CN(CCN(C)C(=O)n1cc(C)cn1)Cc1ccc(OCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: