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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50507208
Substrate
n/a
Meas. Tech.
ChEMBL_1829443 (CHEMBL4329317)
Ki
5.7±n/a nM
Citation
 Lalut, J; Santoni, G; Karila, D; Lecoutey, C; Davis, A; Nachon, F; Silman, I; Sussman, J; Weik, M; Maurice, T; Dallemagne, P; Rochais, C Novel multitarget-directed ligands targeting acetylcholinesterase and ? Eur J Med Chem 162:234-248 (2019) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50507208
Synonyms:
CHEMBL4526050
Type:
Small organic molecule
Emp. Form.:
C24H27ClN2O2
Mol. Mass.:
410.936
SMILES:
COc1c(cc(Cl)c2[nH]ccc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Structure:
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