Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50507255
Substrate
n/a
Meas. Tech.
ChEMBL_1829480 (CHEMBL4329354)
IC50
630±n/a nM
Citation
 Fleming, CL; Natoli, A; Schreuders, J; Devlin, M; Yoganantharajah, P; Gibert, Y; Leslie, KG; New, EJ; Ashton, TD; Pfeffer, FM Highly fluorescent and HDAC6 selective scriptaid analogues. Eur J Med Chem 162:321-333 (2019) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50507255
Synonyms:
CHEMBL4465218
Type:
Small organic molecule
Emp. Form.:
C18H17N3O6
Mol. Mass.:
371.3441
SMILES:
ONC(=O)CCCCCN1C(=O)c2cccc3c(ccc(C1=O)c23)[N+]([O-])=O
Structure:
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