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Target
Mitogen-activated protein kinase 14
Ligand
BDBM25980
Substrate
n/a
Meas. Tech.
ChEMBL_1837226 (CHEMBL4337359)
Ki
240±n/a nM
Citation
 Astolfi, A; Kudolo, M; Brea, J; Manni, G; Manfroni, G; Palazzotti, D; Sabatini, S; Cecchetti, F; Felicetti, T; Cannalire, R; Massari, S; Tabarrini, O; Loza, MI; Fallarino, F; Cecchetti, V; Laufer, SA; Barreca, ML Discovery of potent p38? MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Human
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM25980
Synonyms:
BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide | biphenyl amide, 3
Type:
Small organic molecule
Emp. Form.:
C24H18N4O2
Mol. Mass.:
394.4253
SMILES:
Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)Nc1cccc(c1)C#N
Structure:
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