Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50063289
Substrate
n/a
Meas. Tech.
ChEMBL_62432 (CHEMBL674835)
Ki
54±n/a nM
Citation
 Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41:760-71 (1998) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50063289
Synonyms:
CHEMBL165140 | {4-[3-(4-Phenyl-piperazin-1-yl)-propyl]-cyclohexyl}-pyrimidin-2-yl-amine
Type:
Small organic molecule
Emp. Form.:
C23H33N5
Mol. Mass.:
379.5416
SMILES:
C(C[C@H]1CC[C@@H](CC1)Nc1ncccn1)CN1CCN(CC1)c1ccccc1 |wU:5.8,wD:2.1,(7.79,-8.8,;6.25,-8.89,;5.4,-7.59,;6.11,-6.22,;5.26,-4.94,;3.72,-5.01,;3.03,-6.39,;3.87,-7.7,;2.88,-3.72,;3.56,-2.34,;2.72,-1.06,;3.42,.32,;4.97,.4,;5.81,-.89,;5.11,-2.27,;8.63,-10.11,;10.18,-10.01,;11.02,-11.32,;12.56,-11.24,;13.25,-9.86,;12.41,-8.56,;10.88,-8.64,;14.79,-9.78,;15.63,-11.07,;17.16,-10.97,;17.86,-9.61,;16.99,-8.31,;15.47,-8.41,)|
Structure:
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