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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50064681
Substrate
n/a
Meas. Tech.
ChEMBL_123282 (CHEMBL731803)
IC50
800±n/a nM
Citation
 Harfenist, M; McGee, DP; Reeves, MD; White, HL Selective inhibitors of monoamine oxidase (MAO). 5. 1-Substituted phenoxathiin inhibitors containing no nitrogen that inhibit MAO A by binding it to a hydrophobic site. J Med Chem 41:2118-25 (1998) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA)
Type:
Enzyme
Mol. Mass.:
59515.21
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
526
Sequence:
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
  
Inhibitor
Name:
BDBM50064681
Synonyms:
4-Methyl-phenoxathiine 10,10-dioxide | CHEMBL66219
Type:
Small organic molecule
Emp. Form.:
C13H10O3S
Mol. Mass.:
246.282
SMILES:
Cc1cccc2c1Oc1ccccc1S2(=O)=O
Structure:
Search PDB for entries with ligand similarity: