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Target
Tryptase beta-2
Ligand
BDBM50511186
Substrate
n/a
Meas. Tech.
ChEMBL_1844054 (CHEMBL4344481)
IC50
2160±n/a nM
Citation
 Giardina, SF; Werner, DS; Pingle, M; Feinberg, PB; Foreman, KW; Bergstrom, DE; Arnold, LD; Barany, F Novel, Self-Assembling Dimeric Inhibitors of Human ? Tryptase. J Med Chem 63:3004-3027 (2020) [PubMed]  Article 
Target
Name:
Tryptase beta-2
Synonyms:
3.4.21.59 | Mast cell protease 6 | Mcpt6 | TRYB2_MOUSE | Tpsb2 | Tryptase beta-2 | Tryptase-2 | mMCP-6
Type:
PROTEIN
Mol. Mass.:
30933.64
Organism:
Mus musculus
Description:
ChEMBL_118951
Residue:
276
Sequence:
MLKRRLLLLWALSLLASLVYSAPRPANQRVGIVGGHEASESKWPWQVSLRFKLNYWIHFCGGSLIHPQWVLTAAHCVGPHIKSPQLFRVQLREQYLYYGDQLLSLNRIVVHPHYYTAEGGADVALLELEVPVNVSTHIHPISLPPASETFPPGTSCWVTGWGDIDNDEPLPPPYPLKQVKVPIVENSLCDRKYHTGLYTGDDFPIVHDGMLCAGNTRRDSCQGDSGGPLVCKVKGTWLQAGVVSWGEGCAQPNKPGIYTRVTYYLDWIHRYVPEHS
  
Inhibitor
Name:
BDBM50511186
Synonyms:
CHEMBL4553079
Type:
Small organic molecule
Emp. Form.:
C22H25N3O5
Mol. Mass.:
411.451
SMILES:
CONC(=O)c1cc(ccc1O)C(=O)N1CCC2(COc3ccc(CN)cc23)CC1
Structure:
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