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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50066927
Substrate
n/a
Meas. Tech.
ChEMBL_195845 (CHEMBL799144)
IC50
150±n/a nM
Citation
 Nugent, RA; Schlachter, ST; Murphy, MJ; Cleek, GJ; Poel, TJ; Wishka, DG; Graber, DR; Yagi, Y; Keiser, BJ; Olmsted, RA; Kopta, LA; Swaney, SM; Poppe, SM; Morris, J; Tarpley, WG; Thomas, RC Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV. J Med Chem 41:3793-803 (1998) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus type 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50066927
Synonyms:
6-Chloro-2-(naphthalen-2-ylmethylsulfanyl)-pyrimidin-4-ylamine | CHEMBL124494
Type:
Small organic molecule
Emp. Form.:
C15H12ClN3S
Mol. Mass.:
301.794
SMILES:
Nc1cc(Cl)nc(SCc2ccc3ccccc3c2)n1
Structure:
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