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Target
Glutaminase kidney isoform, mitochondrial
Ligand
BDBM50512566
Substrate
n/a
Meas. Tech.
ChEMBL_1849668 (CHEMBL4350209)
Kd
142±n/a nM
Citation
 Hou, W; Fang, J; Su, L; Ye, H; Ruan, BH Design and synthesis of biotinylated Hexylselen as a probe to identify KGA allosteric inhibitors by a convenient biomolecular interaction assay. Bioorg Med Chem Lett 29:2498-2502 (2019) [PubMed]  Article 
Target
Name:
Glutaminase kidney isoform, mitochondrial
Synonyms:
GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase
Type:
Protein
Mol. Mass.:
73471.89
Organism:
Homo sapiens (Human)
Description:
O94925
Residue:
669
Sequence:
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
  
Inhibitor
Name:
BDBM50512566
Synonyms:
CHEMBL4444708
Type:
Small organic molecule
Emp. Form.:
C31H38N4O5SSe2
Mol. Mass.:
736.64
SMILES:
[H][C@]12[#6]-[#16]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#6]-[#8]-c3ccc4[se;v2]n(-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-n5[se;v2]c6ccc(-[#8]-[#6])cc6c5=O)c(=O)c4c3)[C@@]1([H])[#7]-[#6](=O)-[#7]2 |r|
Structure:
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