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Target
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Ligand
BDBM50512785
Substrate
n/a
Meas. Tech.
ChEMBL_1850349 (CHEMBL4350890)
IC50
>30000±n/a nM
Citation
 Sun, AW; Bulterys, PL; Bartberger, MD; Jorth, PA; O'Boyle, BM; Virgil, SC; Miller, JF; Stoltz, BM Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. Bioorg Med Chem Lett 29:2686-2689 (2019) [PubMed]  Article 
Target
Name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Synonyms:
1.3.5.1 | Flavoprotein subunit of complex II | SDH2 | SDHA | SDHA_HUMAN | SDHF | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
72700.80
Organism:
Homo sapiens
Description:
ChEMBL_101537
Residue:
664
Sequence:
MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPAIRSY
  
Inhibitor
Name:
BDBM50512785
Synonyms:
CHEMBL4452261
Type:
Small organic molecule
Emp. Form.:
C20H26FN3O5
Mol. Mass.:
407.4359
SMILES:
CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCO[C@]3(CCCOC3)C2)c(F)c1 |r|
Structure:
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