Reaction Details Report a problem with these data
Target
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Ligand
BDBM50512786
Substrate
n/a
Meas. Tech.
ChEMBL_1850349 (CHEMBL4350890)
IC50
30000±n/a nM
Citation
Sun, AW; Bulterys, PL; Bartberger, MD; Jorth, PA; O'Boyle, BM; Virgil, SC; Miller, JF; Stoltz, BM Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. Bioorg Med Chem Lett 29:2686-2689 (2019) [PubMed] Article
More Info.:
Target
Name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Synonyms:
1.3.5.1 | Flavoprotein subunit of complex II | SDH2 | SDHA | SDHA_HUMAN | SDHF | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
72700.80
Organism:
Homo sapiens
Description:
ChEMBL_101537
Residue:
664
Sequence:
MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPAIRSY