Reaction Details
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5-hydroxytryptamine receptor 6
Ligand
BDBM50513389
Substrate
n/a
Meas. Tech.
ChEMBL_1853390 (CHEMBL4354014)
Ki
78±n/a nM
Citation
Hogendorf, AS; Hogendorf, A; Kurczab, R; Kalinowska-T?u?cik, J; Popik, P; Nikiforuk, A; Krawczyk, M; Sata?a, G; Lenda, T; Knutelska, J; Bugno, R; Staro?, J; Pietru?, W; Mat?oka, M; Dubiel, K; Moszczy?ski-P?tkowski, R; Pieczykolan, J; Wieczorek, M; Pilarski, B; Zajdel, P; Bojarski, AJ 2-Aminoimidazole-based antagonists of the 5-HT Eur J Med Chem 179:1-15 (2019) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
Inhibitor
Name:
BDBM50513389
Synonyms:
CHEMBL4455699
Type:
Small organic molecule
Emp. Form.:
C23H20BrN3O3S
Mol. Mass.:
498.392
SMILES:
[Br-].COc1ccc2n(cc(-c3[nH]c4cccc[n+]4c3C)c2c1)S(=O)(=O)c1ccccc1
Structure:
