Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50514208
Substrate
n/a
Meas. Tech.
ChEMBL_1855858 (CHEMBL4356587)
Ki
0.280000±n/a nM
Citation
Rescourio, G; Gonzalez, AZ; Jabri, S; Belmontes, B; Moody, G; Whittington, D; Huang, X; Caenepeel, S; Cardozo, M; Cheng, AC; Chow, D; Dou, H; Jones, A; Kelly, RC; Li, Y; Lizarzaburu, M; Lo, MC; Mallari, R; Meleza, C; Rew, Y; Simonovich, S; Sun, D; Turcotte, S; Yan, X; Wong, SG; Yanez, E; Zancanella, M; Houze, J; Medina, JC; Hughes, PE; Brown, SP Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an ?-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere. J Med Chem 62:10258-10271 (2019) [PubMed] Article
More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Human
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR