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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50396352
Substrate
n/a
Meas. Tech.
ChEMBL_1855924 (CHEMBL4356653)
Ki
17±n/a nM
Citation
 García, M; Virgili, M; Alonso, M; Alegret, C; Fernández, B; Port, A; Pascual, R; Monroy, X; Vidal-Torres, A; Serafini, MT; Vela, JM; Almansa, C 4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual ?-Opioid Receptor Agonists and ? J Med Chem 63:2434-2454 (2020) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Human
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50396352
Synonyms:
CHEMBL2170062
Type:
Small organic molecule
Emp. Form.:
C20H23N3O2
Mol. Mass.:
337.4155
SMILES:
Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1
Structure:
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