Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM50514552
Substrate
n/a
Meas. Tech.
ChEMBL_1857511 (CHEMBL4358240)
EC50
>10000±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Human
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50514552
Synonyms:
CHEMBL4594096
Type:
Small organic molecule
Emp. Form.:
C29H47N7O
Mol. Mass.:
509.7298
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CNC(=O)[C@@H](N)CCCNC(N)=N)c2ccccc12 |r,wU:22.24,wD:6.9,3.2,(63.55,-38.33,;62.74,-37.01,;63.48,-35.65,;61.19,-37.05,;60.38,-35.75,;58.84,-35.79,;58.11,-37.14,;58.92,-38.46,;60.46,-38.41,;56.57,-37.2,;55.84,-38.56,;54.3,-38.61,;53.48,-37.3,;54.2,-35.94,;55.75,-35.89,;51.94,-37.36,;51,-36.14,;49.55,-36.67,;48.27,-35.81,;46.89,-36.48,;45.62,-35.63,;45.72,-34.09,;44.24,-36.3,;44.13,-37.84,;42.96,-35.45,;41.58,-36.12,;40.3,-35.26,;38.92,-35.94,;37.65,-35.08,;36.27,-35.76,;37.75,-33.55,;49.61,-38.21,;48.5,-39.28,;48.87,-40.77,;50.36,-41.19,;51.46,-40.12,;51.09,-38.64,)|
Structure:
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