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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50514753
Substrate
n/a
Meas. Tech.
ChEMBL_1858292 (CHEMBL4359021)
IC50
21±n/a nM
Citation
 Serafini, M; Torre, E; Aprile, S; Grosso, ED; Gesł, A; Griglio, A; Colombo, G; Travelli, C; Paiella, S; Adamo, A; Orecchini, E; Coletti, A; Pallotta, MT; Ugel, S; Massarotti, A; Pirali, T; Fallarini, S Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to  J Med Chem 63:3047-3065 (2020) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50514753
Synonyms:
CHEMBL4557994
Type:
Small organic molecule
Emp. Form.:
C20H17BrN4O
Mol. Mass.:
409.279
SMILES:
Brc1c[nH]c(c1)C(=O)NCc1cccc(Cn2cnc3ccccc23)c1
Structure:
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