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Target
Proteasome subunit beta type-8
Ligand
BDBM50516220
Substrate
n/a
Meas. Tech.
ChEMBL_1863868 (CHEMBL4364843)
IC50
100±n/a nM
Citation
 Zhan, W; Visone, J; Ouellette, T; Harris, JC; Wang, R; Zhang, H; Singh, PK; Ginn, J; Sukenick, G; Wong, TT; Okoro, JI; Scales, RM; Tumwebaze, PK; Rosenthal, PJ; Kafsack, BFC; Cooper, RA; Meinke, PT; Kirkman, LA; Lin, G Improvement of Asparagine Ethylenediamines as Anti-malarial  J Med Chem 62:6137-6145 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM50516220
Synonyms:
CHEMBL4445784
Type:
Small organic molecule
Emp. Form.:
C24H32N4O5S
Mol. Mass.:
488.6
SMILES:
Cc1ccc(cc1)S(=O)(=O)N[C@@H](CC(=O)NC(C)(C)C)C(=O)NCCNC(=O)c1ccccc1 |r|
Structure:
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