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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50516392
Substrate
n/a
Meas. Tech.
ChEMBL_1864571 (CHEMBL4365546)
IC50
360±n/a nM
Citation
Myers, SM; Miller, DC; Molyneux, L; Arasta, M; Bawn, RH; Blackburn, TJ; Cook, SJ; Edwards, N; Endicott, JA; Golding, BT; Griffin, RJ; Hammonds, T; Hardcastle, IR; Harnor, SJ; Heptinstall, AB; Lochhead, PA; Martin, MP; Martin, NC; Newell, DR; Owen, PJ; Pang, LC; Reuillon, T; Rigoreau, LJM; Thomas, HD; Tucker, JA; Wang, LZ; Wong, AC; Noble, MEM; Wedge, SR; Cano, C Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38? and BRD4. Eur J Med Chem 178:530-543 (2019) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES