Reaction Details Report a problem with these data
Target
Cereblon isoform 4
Ligand
BDBM50516603
Substrate
n/a
Meas. Tech.
ChEMBL_1866003 (CHEMBL4366978)
Ki
12000±n/a nM
Citation
 Heim, C; Pliatsika, D; Mousavizadeh, F; Bär, K; Hernandez Alvarez, B; Giannis, A; Hartmann, MD De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem 62:6615-6629 (2019) [PubMed]  Article 
Target
Name:
Cereblon isoform 4
Synonyms:
Cereblon isoform 4
Type:
PROTEIN
Mol. Mass.:
13620.40
Organism:
Magnetospirillum gryphiswaldense
Description:
ChEMBL_116733
Residue:
124
Sequence:
MPLDAGGQNSTQMVLAPGASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPAD
  
Inhibitor
Name:
BDBM50516603
Synonyms:
CHEMBL4563318
Type:
Small organic molecule
Emp. Form.:
C17H19N3O7
Mol. Mass.:
377.3487
SMILES:
OC(=O)CCC(=O)NCc1ccc(COC(=O)NC2CC(=O)NC2=O)cc1
Structure:
Search PDB for entries with ligand similarity: