Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074414
Substrate
n/a
Meas. Tech.
ChEMBL_51111 (CHEMBL666549)
Ki
22±n/a nM
Citation
 Arvanitis, AG; Gilligan, PJ; Chorvat, RJ; Cheeseman, RS; Christos, TE; Bakthavatchalam, R; Beck, JP; Cocuzza, AJ; Hobbs, FW; Wilde, RG; Arnold, C; Chidester, D; Curry, M; He, L; Hollis, A; Klaczkiewicz, J; Krenitsky, PJ; Rescinito, JP; Scholfield, E; Culp, S; De Souza, EB; Fitzgerald, L; Grigoriadis, D; Tam, SW; Shen, HL Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines. J Med Chem 42:805-18 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074414
Synonyms:
CHEMBL167737 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N*2*,N*4*-diethyl-N*4*-(2-methoxy-ethyl)-6-methyl-pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C21H31BrN4O
Mol. Mass.:
435.401
SMILES:
CCN(CCOC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Structure:
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