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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074411
Substrate
n/a
Meas. Tech.
ChEMBL_51111 (CHEMBL666549)
Ki
12±n/a nM
Citation
 Arvanitis, AG; Gilligan, PJ; Chorvat, RJ; Cheeseman, RS; Christos, TE; Bakthavatchalam, R; Beck, JP; Cocuzza, AJ; Hobbs, FW; Wilde, RG; Arnold, C; Chidester, D; Curry, M; He, L; Hollis, A; Klaczkiewicz, J; Krenitsky, PJ; Rescinito, JP; Scholfield, E; Culp, S; De Souza, EB; Fitzgerald, L; Grigoriadis, D; Tam, SW; Shen, HL Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines. J Med Chem 42:805-18 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074411
Synonyms:
(2-Bromo-4,6-dimethoxy-phenyl)-(4,6-dimethyl-pyrimidin-2-yl)-ethyl-amine | CHEMBL46479
Type:
Small organic molecule
Emp. Form.:
C16H20BrN3O2
Mol. Mass.:
366.253
SMILES:
CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC
Structure:
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