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Target
Fatty-acid amide hydrolase 1 [30-579]
Ligand
BDBM50520756
Substrate
n/a
Meas. Tech.
ChEMBL_1882118 (CHEMBL4383617)
IC50
50±n/a nM
Citation
 Garzinsky, D; Zahov, S; Ekodo Voundi, M; Hanekamp, W; Lehr, M Tetrazolylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability. Eur J Med Chem 160:183-192 (2018) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [30-579]
Synonyms:
Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:
Single-pass membrane protein; homodimer
Mol. Mass.:
60474.00
Organism:
Rattus norvegicus (rat)
Description:
P97612 (aa 30-579)
Residue:
550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
  
Inhibitor
Name:
BDBM50520756
Synonyms:
CHEMBL4466825
Type:
Small organic molecule
Emp. Form.:
C26H32N4O4
Mol. Mass.:
464.5567
SMILES:
CCCCCCCCc1ccc(OC(C)C(=O)Cn2nnc(n2)-c2ccc(cc2)C(O)=O)cc1
Structure:
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