Reaction Details Report a problem with these data
Target
Lipoprotein lipase
Ligand
BDBM24567
Substrate
n/a
Meas. Tech.
ChEMBL_1883778 (CHEMBL4385277)
IC50
66±n/a nM
Citation
Johnson, JA; Tora, G; Pi, Z; Phillips, M; Yin, X; Yang, R; Zhao, L; Chen, AY; Taylor, DS; Basso, M; Rose, A; Behnia, K; Onorato, J; Chen, XQ; Abell, LM; Lu, H; Locke, G; Caporuscio, C; Galella, M; Adam, LP; Gordon, D; Wexler, RR; Finlay, HJ Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase. ACS Med Chem Lett 9:1263-1268 (2018) [PubMed] Article
More Info.:
Target
Name:
Lipoprotein lipase
Synonyms:
LIPD | LIPL_HUMAN | LPL
Type:
PROTEIN
Mol. Mass.:
53173.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1280894
Residue:
475
Sequence:
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
Inhibitor
Name:
BDBM24567
Synonyms:
(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate | CHEMBL175247 | Orlistat | THLP | Tetrahydrolipstatin | US9328123, Orlistat | Xenical
Type:
Small organic molecule
Emp. Form.:
C29H53NO5
Mol. Mass.:
495.7348
SMILES:
CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r|