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Target
Lipoprotein lipase
Ligand
BDBM50521226
Substrate
n/a
Meas. Tech.
ChEMBL_1883778 (CHEMBL4385277)
IC50
12000±n/a nM
Citation
 Johnson, JA; Tora, G; Pi, Z; Phillips, M; Yin, X; Yang, R; Zhao, L; Chen, AY; Taylor, DS; Basso, M; Rose, A; Behnia, K; Onorato, J; Chen, XQ; Abell, LM; Lu, H; Locke, G; Caporuscio, C; Galella, M; Adam, LP; Gordon, D; Wexler, RR; Finlay, HJ Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase. ACS Med Chem Lett 9:1263-1268 (2018) [PubMed]  Article 
Target
Name:
Lipoprotein lipase
Synonyms:
LIPD | LIPL_HUMAN | LPL
Type:
PROTEIN
Mol. Mass.:
53173.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1280894
Residue:
475
Sequence:
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
  
Inhibitor
Name:
BDBM50521226
Synonyms:
CHEMBL4471545
Type:
Small organic molecule
Emp. Form.:
C18H17N5O5S3
Mol. Mass.:
479.553
SMILES:
CS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Structure:
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