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Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50523738
Substrate
n/a
Meas. Tech.
ChEMBL_1891034 (CHEMBL4392788)
IC50
470±n/a nM
Citation
 Ma, T; Huang, M; Li, A; Zhao, F; Li, D; Liu, D; Zhao, L Design, synthesis and biological evaluation of benzimidazole derivatives as novel human Pin1 inhibitors. Bioorg Med Chem Lett 29:1859-1863 (2019) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
  
Inhibitor
Name:
BDBM50523738
Synonyms:
CHEMBL4587244
Type:
Small organic molecule
Emp. Form.:
C25H23ClN2O3
Mol. Mass.:
434.915
SMILES:
Cc1cc(OCCCn2c(nc3ccccc23)-c2ccc(cc2)C(O)=O)cc(C)c1Cl
Structure:
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