Reaction Details Report a problem with these data
Target
H2-K region expressed gene 2, rat orthologue
Ligand
BDBM50079837
Substrate
n/a
Meas. Tech.
ChEBML_103872
IC50
340±n/a nM
Citation
Jones, AB; Acton, JJ; Rivetna, MN; Cummings, RT; Cubbon, RM; Nichols, EA; Schwartz, CD; Wicker, LS; Hermes, JD Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate. Bioorg Med Chem Lett 9:2109-14 (1999) [PubMed] Article
More Info.:
Target
Name:
H2-K region expressed gene 2, rat orthologue
Synonyms:
MHC class II | MHC class II region expressed gene KE2, isoform CRA_a
Type:
PROTEIN
Mol. Mass.:
14499.39
Organism:
Rattus norvegicus
Description:
ChEMBL_10342
Residue:
127
Sequence:
MAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLDGSNVVFKLLGPVLVKQELGEARATVGKRLDYITAEIKRYESQLRDLERQSEQQRETLAQLQQEFQRAQNAKAPGKA
Inhibitor
Name:
BDBM50079837
Synonyms:
(S)-2-[(R)-3-((E)-3-Cycloheptyl-allylamino)-2-oxo-pyrrolidin-1-yl]-pentanoic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide | CHEMBL417576
Type:
Small organic molecule
Emp. Form.:
C25H44N4O3
Mol. Mass.:
448.6419
SMILES:
CCC[C@H](N1CC[C@@H](NC\C=C\C2CCCCCC2)C1=O)C(=O)N[C@@H](CC(C)C)C(N)=O