Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-2
Ligand
BDBM50144858
Substrate
n/a
Meas. Tech.
ChEMBL_1901495 (CHEMBL4403717)
Ki
0.580000±n/a nM
Citation
 Maramai, S; Benchekroun, M; Ward, SE; Atack, JR Subtype Selective ?-Aminobutyric Acid Type A Receptor (GABA J Med Chem 63:3425-3446 (2020) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-2
Synonyms:
GABA receptor alpha-2 subunit | GABRA2 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)
Type:
Protein
Mol. Mass.:
51338.78
Organism:
Homo sapiens (Human)
Description:
P47869
Residue:
451
Sequence:
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
  
Inhibitor
Name:
BDBM50144858
Synonyms:
3-(5-Methyl-isoxazol-3-yl)-6-(1-methyl-1H-[1,2,3]triazol-4-ylmethoxy)-[1,2,4]triazolo[3,4-a]phthalazine | CHEMBL306422
Type:
Small organic molecule
Emp. Form.:
C17H14N8O2
Mol. Mass.:
362.3455
SMILES:
Cc1cc(no1)-c1nnc2c3ccccc3c(OCc3cn(C)nn3)nn12
Structure:
Search PDB for entries with ligand similarity: