Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50082224
Substrate
n/a
Meas. Tech.
ChEBML_105816
IC50
>10000±n/a nM
Citation
Bailey, S; Bolognese, B; Faller, A; Louis-Flamberg, P; MacPherson, DT; Mayer, RJ; Marshall, LA; Milner, PH; Mistry, J; Smith, DG; Ward, JG Selective inhibition of low affinity IgE receptor (CD23) processing: P1' bicyclomethyl substituents. Bioorg Med Chem Lett 9:3165-70 (1999) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50082224
Synonyms:
(2R,3S)-N*4*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2,N*1*-dihydroxy-3-(7-hydroxy-naphthalen-2-ylmethyl)-succinamide | CHEMBL106444
Type:
Small organic molecule
Emp. Form.:
C24H25N3O6
Mol. Mass.:
451.4718
SMILES:
NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc2ccc(O)cc2c1)[C@H](O)C(=O)NO