Reaction Details Report a problem with these data
Target
Cytochrome P450 4F12
Ligand
BDBM50527963
Substrate
n/a
Meas. Tech.
ChEMBL_1904210 (CHEMBL4406432)
IC50
167000±n/a nM
Citation
 Kowalski, JP; McDonald, MG; Pelletier, RD; Hanenberg, H; Wiek, C; Rettie, AE Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1. J Med Chem 63:4824-4836 (2020) [PubMed]  Article 
Target
Name:
Cytochrome P450 4F12
Synonyms:
1.14.14.1 | CP4FC_HUMAN | CYP4F12 | CYPIVF12 | Cytochrome P450 4F12
Type:
PROTEIN
Mol. Mass.:
60317.77
Organism:
Homo sapiens
Description:
ChEMBL_109678
Residue:
524
Sequence:
MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ
  
Inhibitor
Name:
BDBM50527963
Synonyms:
CHEMBL4557940
Type:
Small organic molecule
Emp. Form.:
C14H20N4O2
Mol. Mass.:
276.3342
SMILES:
OC(=O)CCCCCCCNn1nnc2ccccc12
Structure:
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