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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50529065
Substrate
n/a
Meas. Tech.
ChEMBL_1907196 (CHEMBL4409554)
IC50
12400±n/a nM
Citation
 Zou, Y; Hu, Y; Ge, S; Zheng, Y; Li, Y; Liu, W; Guo, W; Zhang, Y; Xu, Q; Lai, Y Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors. Eur J Med Chem 184:0 (2019) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50529065
Synonyms:
CHEMBL4437675
Type:
Small organic molecule
Emp. Form.:
C19H14ClN3O3S
Mol. Mass.:
399.851
SMILES:
Clc1ccc(cc1)-c1csc2ncn(CC(=O)NCc3ccco3)c(=O)c12
Structure:
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