Reaction Details
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Estrogen-related receptor gamma
Ligand
BDBM50530057
Substrate
n/a
Meas. Tech.
ChEMBL_1911359 (CHEMBL4413805)
IC50
60±n/a nM
Citation
Kim, J; Song, J; Ji, HD; Yoo, EK; Lee, JE; Lee, SB; Oh, JM; Lee, S; Hwang, JS; Yoon, H; Kim, DS; Lee, SJ; Jeong, M; Lee, S; Kim, KH; Choi, HS; Lee, SW; Park, KG; Lee, IK; Kim, SH; Hwang, H; Jeon, YH; Chin, J; Cho, SJ Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-? Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J Med Chem 62:1837-1858 (2019) [PubMed] Article More Info.:
Target
Name:
Estrogen-related receptor gamma
Synonyms:
ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3
Type:
PROTEIN
Mol. Mass.:
51305.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1501351
Residue:
458
Sequence:
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
Inhibitor
Name:
BDBM50530057
Synonyms:
CHEMBL4438589
Type:
Small organic molecule
Emp. Form.:
C28H34Cl2N2O2
Mol. Mass.:
501.488
SMILES:
Cl.Cl.CN1CCN(CC1)c1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Structure:
