Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50340726
Substrate
n/a
Meas. Tech.
ChEMBL_1923442 (CHEMBL4426398)
Ki
2.1±n/a nM
Citation
 Zajdel, PMarciniec, KSata?a, GCanale, VKos, TPartyka, AJastrz?bska-Wi?sek, MWeso?owska, ABasi?ska-Ziobro?, AWójcikowski, JDaniel, WABojarski, AJPopik, P N1-Azinylsulfonyl-1H-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties. ACS Med Chem Lett 7:618-22 (2016) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50340726
Synonyms:
5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine | CHEMBL1668500 | US8552005, 1.1(5)
Type:
Small organic molecule
Emp. Form.:
C15H15N3O2S2
Mol. Mass.:
333.429
SMILES:
CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: