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Target
Galectin-8
Ligand
BDBM50533579
Substrate
n/a
Meas. Tech.
ChEMBL_1925944 (CHEMBL4429016)
Kd
84000±n/a nM
Citation
 Rajput, VK; MacKinnon, A; Mandal, S; Collins, P; Blanchard, H; Leffler, H; Sethi, T; Schambye, H; Mukhopadhyay, B; Nilsson, UJ A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model. J Med Chem 59:8141-7 (2016) [PubMed]  Article 
Target
Name:
Galectin-8
Synonyms:
Gal-8 | LEG8_HUMAN | LGALS8 | PCTA-1 | Po66 carbohydrate-binding protein | Po66-CBP | Prostate carcinoma tumor antigen 1
Type:
PROTEIN
Mol. Mass.:
35814.23
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454625
Residue:
317
Sequence:
MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW
  
Inhibitor
Name:
BDBM50533579
Synonyms:
CHEMBL4519227
Type:
Small organic molecule
Emp. Form.:
C34H38O16S
Mol. Mass.:
734.721
SMILES:
[H][C@]1(O[C@H](CO)[C@H](O)[C@H](OCc2cc3ccc(OC)cc3oc2=O)[C@H]1O)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](OCc2cc3ccc(OC)cc3oc2=O)[C@H]1O |r|
Structure:
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