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Target
B1 bradykinin receptor
Ligand
BDBM50089315
Substrate
n/a
Meas. Tech.
ChEMBL_40131 (CHEMBL656784)
Ki
24.1±n/a nM
Citation
 Bedos, P; Amblard, M; Subra, G; Dodey, P; Luccarini, JM; Paquet, JL; Pruneau, D; Aumelas, A; Martinez, J A rational approach to the design and synthesis of a new bradykinin B(1) receptor antagonist. J Med Chem 43:2387-94 (2000) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50089315
Synonyms:
CHEMBL80461 | {3-[2-(2-{8-[2-(2,6-Diamino-hexanoylamino)-5-guanidino-pentanoyl]-4-oxo-1-phenethyl-1,3,8-triaza-spiro[4.5]dec-3-yl}-acetylamino)-3-hydroxy-propionylamino]-4-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazepin-5-yl}-acetic acid(JMV1640)
Type:
Small organic molecule
Emp. Form.:
C43H62N12O9S
Mol. Mass.:
923.092
SMILES:
NCCCCC(N)C(=O)NC(CCCNC(N)=N)C(=O)N1CCC2(CC1)N(CCc1ccccc1)CN(CC(=O)NC(CO)C(=O)N[C@@H]1CSc3ccccc3N(CC(O)=O)C1=O)C2=O
Structure:
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