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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50533863
Substrate
n/a
Meas. Tech.
ChEMBL_1927524 (CHEMBL4430596)
IC50
1.6±n/a nM
Citation
 Kim, SM; Lee, M; Lee, SY; Park, E; Lee, SM; Kim, EJ; Han, MY; Yoo, T; Ann, J; Yoon, S; Lee, J; Lee, J Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist. J Med Chem 59:9150-9172 (2016) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50533863
Synonyms:
CHEMBL4593521
Type:
Small organic molecule
Emp. Form.:
C36H38F5N5O5
Mol. Mass.:
715.7094
SMILES:
COc1cccc(N2CCN(CC2)c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](NCCCC(O)=O)c3ccccc3)c2=O)c1F |r|
Structure:
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