Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM50535160
Substrate
n/a
Meas. Tech.
ChEMBL_1929930 (CHEMBL4433106)
Ki
2.3±n/a nM
Citation
 Rosse, G Treatment of Pain with Spirocylic Cyclohexane Derivatives Having Dual Specificity for ORL-1 and ?-Opioid Receptors. ACS Med Chem Lett 7:822-3 (2016) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50535160
Synonyms:
CHEMBL4517646
Type:
Small organic molecule
Emp. Form.:
C24H35N3
Mol. Mass.:
365.5548
SMILES:
CN(C)C1(CCC2(CCN(CCC3(CCC3)C#N)C2)CC1)c1ccccc1 |(43.54,-13.69,;42.05,-13.3,;41.64,-11.82,;40.96,-14.4,;40.19,-15.72,;38.67,-15.72,;37.9,-14.39,;36.88,-13.23,;35.45,-13.85,;35.6,-15.39,;34.45,-16.41,;32.99,-15.92,;31.83,-16.94,;31.05,-18.28,;32.38,-19.05,;33.16,-17.72,;30.37,-16.45,;28.92,-15.95,;37.11,-15.73,;38.67,-13.06,;40.2,-13.07,;42.05,-15.49,;41.65,-16.97,;42.73,-18.05,;44.21,-17.65,;44.61,-16.16,;43.52,-15.09,)|
Structure:
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