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Target
Mu-type opioid receptor
Ligand
BDBM50535171
Substrate
n/a
Meas. Tech.
ChEMBL_1929931 (CHEMBL4433107)
Ki
1.2±n/a nM
Citation
 Rosse, G Treatment of Pain with Spirocylic Cyclohexane Derivatives Having Dual Specificity for ORL-1 and ?-Opioid Receptors. ACS Med Chem Lett 7:822-3 (2016) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Human
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50535171
Synonyms:
CHEMBL4536065
Type:
Small organic molecule
Emp. Form.:
C24H33N3O
Mol. Mass.:
379.5383
SMILES:
CN(C)C1(CCC2(CN(CCC3(CCC3)C#N)C(=O)C2)CC1)c1ccccc1 |(43.54,-13.69,;42.05,-13.3,;41.64,-11.82,;40.96,-14.4,;40.19,-15.72,;38.67,-15.72,;37.9,-14.39,;37.11,-15.73,;35.6,-15.39,;34.45,-16.41,;32.99,-15.92,;31.83,-16.94,;31.05,-18.27,;32.38,-19.05,;33.16,-17.72,;30.37,-16.45,;28.92,-15.95,;35.45,-13.84,;34.12,-13.05,;36.88,-13.23,;38.67,-13.06,;40.2,-13.07,;42.05,-15.49,;41.65,-16.97,;42.73,-18.05,;44.21,-17.65,;44.61,-16.16,;43.52,-15.09,)|
Structure:
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