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Target
Substance-P receptor
Ligand
BDBM50093096
Substrate
n/a
Meas. Tech.
ChEBML_205877
Ki
0.700000±n/a nM
Citation
 Reichard, GA; Ball, ZT; Aslanian, R; Anthes, JC; Shih, NY; Piwinski, JJ The design and synthesis of novel NK1/NK2 dual antagonists. Bioorg Med Chem Lett 10:2329-32 (2001) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50093096
Synonyms:
2-[(1R,2S)-1-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-2-(3,4-dichloro-phenyl)-4-(4-hydroxy-4-phenyl-piperidin-1-yl)-butylamino]-acetamide | CHEMBL306311
Type:
Small organic molecule
Emp. Form.:
C33H35Cl2F6N3O3
Mol. Mass.:
706.546
SMILES:
NC(=O)CN[C@@H](COCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)[C@@H](CCN1CCC(O)(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1
Structure:
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