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Target
Hexokinase-4
Ligand
BDBM50540185
Substrate
n/a
Meas. Tech.
ChEMBL_1980977 (CHEMBL4614239)
EC50
684±n/a nM
Citation
 Hinklin, RJ; Baer, BR; Boyd, SA; Chicarelli, MD; Condroski, KR; DeWolf, WE; Fischer, J; Frank, M; Hingorani, GP; Lee, PA; Neitzel, NA; Pratt, SA; Singh, A; Sullivan, FX; Turner, T; Voegtli, WC; Wallace, EM; Williams, L; Aicher, TD Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50540185
Synonyms:
CHEMBL4639192
Type:
Small organic molecule
Emp. Form.:
C24H25N7O3S3
Mol. Mass.:
555.695
SMILES:
Cc1ncccc1Oc1cc(Sc2ccccn2)cnc1Nc1nc(ns1)C1CCN(CC1)S(C)(=O)=O
Structure:
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