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Target
Histone deacetylase 8
Ligand
BDBM50541237
Substrate
n/a
Meas. Tech.
ChEMBL_1984004 (CHEMBL4617410)
IC50
176±n/a nM
Citation
 Greenwood, SOR; Chan, AWE; Hansen, DF; Marson, CM Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an ?-amino amide as the zinc-binding unit. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50541237
Synonyms:
CHEMBL4641186
Type:
Small organic molecule
Emp. Form.:
C19H23Cl4N3O
Mol. Mass.:
451.217
SMILES:
Cl.Cl.CNCc1ccc2CN(Cc2c1)C(=O)[C@H](N)Cc1ccc(Cl)cc1Cl |r|
Structure:
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