Reaction Details Report a problem with these data
Target
P2Y purinoceptor 14
Ligand
BDBM50541997
Substrate
n/a
Meas. Tech.
ChEMBL_1985762 (CHEMBL4619168)
IC50
38±n/a nM
Citation
 Mufti, F; Jung, YH; Giancotti, LA; Yu, J; Chen, Z; Phung, NB; Jacobson, KA; Salvemini, D P2Y ACS Med Chem Lett 11:1281-1286 (2020) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 14
Synonyms:
G-protein coupled receptor 105 | Gpr105 | P2Y14 | P2Y14_MOUSE | P2ry14 | UDP-glucose receptor
Type:
PROTEIN
Mol. Mass.:
38883.93
Organism:
Mus musculus
Description:
ChEMBL_745158
Residue:
338
Sequence:
MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL
  
Inhibitor
Name:
BDBM50541997
Synonyms:
CHEMBL4649855
Type:
Small organic molecule
Emp. Form.:
C32H28F3NO3
Mol. Mass.:
531.5648
SMILES:
CCC(=O)N1CCC(CC1)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Structure:
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