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Target
Sodium channel subunit beta-2
Ligand
BDBM301817
Substrate
n/a
Meas. Tech.
ChEMBL_1990086 (CHEMBL4623821)
IC50
41±n/a nM
Citation
 Shinozuka, T; Kobayashi, H; Suzuki, S; Tanaka, K; Karanjule, N; Hayashi, N; Tsuda, T; Tokumaru, E; Inoue, M; Ueda, K; Kimoto, H; Domon, Y; Takahashi, S; Kubota, K; Yokoyama, T; Shimizugawa, A; Koishi, R; Fujiwara, C; Asano, D; Sakakura, T; Takasuna, K; Abe, Y; Watanabe, T; Kitano, Y Discovery of DS-1971a, a Potent, Selective Na J Med Chem 63:10204-10220 (2020) [PubMed]  Article 
Target
Name:
Sodium channel subunit beta-2
Synonyms:
Gm183 | SCN2B_MOUSE | Scn2b | Sodium channel subunit beta-2
Type:
PROTEIN
Mol. Mass.:
24227.48
Organism:
Mus musculus
Description:
ChEMBL_119885
Residue:
215
Sequence:
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTAPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECNNCTEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKMDGEGNAEDGTK
  
Inhibitor
Name:
BDBM301817
Synonyms:
5-Chloro-2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyrazol-5-yl)cycloheptyl]oxy}-N-(pyrimidin-4-yl)benzenesulfonamide | BDBM301818 | US9597330, Example 19 | US9845313, Example 63
Type:
Small organic molecule
Emp. Form.:
C21H23F2N5O3S
Mol. Mass.:
463.501
SMILES:
Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1 |r|
Structure:
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