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Target
Dihydrofolate reductase
Ligand
BDBM50544208
Substrate
n/a
Meas. Tech.
ChEMBL_1991967 (CHEMBL4625702)
IC50
5800±n/a nM
Citation
 Liang, Y; Zeng, D; You, Y; Ma, B; Li, X; Chen, T Designing Dihydrofolate Reductase Inhibitors as X-ray Radiosensitizers to Reverse Radioresistance of Cervical Cancer. ACS Med Chem Lett 11:1421-1428 (2020) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50544208
Synonyms:
CHEMBL4635593
Type:
Small organic molecule
Emp. Form.:
C16H10N8
Mol. Mass.:
314.3042
SMILES:
Nc1nc(N)c2nc3c4cccnc4c4ncccc4c3nc2n1
Structure:
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