Reaction Details Report a problem with these data
Target
P2X purinoceptor 3
Ligand
BDBM50102295
Substrate
n/a
Meas. Tech.
ChEMBL_147552 (CHEMBL751122)
IC50
140±n/a nM
Citation
 Kim, YC; Brown, SG; Harden, TK; Boyer, JL; Dubyak, G; King, BF; Burnstock, G; Jacobson, KA Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem 44:340-9 (2001) [PubMed]  Article 
Target
Name:
P2X purinoceptor 3
Synonyms:
ATP receptor | P2RX3_RAT | P2X purinoceptor 3 | P2X3 | P2rx3 | Purinergic receptor | ratp2x3 | ratp2x3 + rsa
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44397.63
Organism:
RAT
Description:
Purinergic, P2X3 0 RAT::P49654
Residue:
397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDSQCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEEVTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
  
Inhibitor
Name:
BDBM50102295
Synonyms:
4-(4-Formyl-5-hydroxy-6-methyl-3-phosphonooxymethyl-pyridin-2-ylazo)-benzoic acid | CHEMBL119235
Type:
Small organic molecule
Emp. Form.:
C15H14N3O8P
Mol. Mass.:
395.2607
SMILES:
Cc1nc(N=Nc2ccc(cc2)C(O)=O)c(COP(O)(O)=O)c(C=O)c1O |w:5.5|
Structure:
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