Reaction Details Report a problem with these data
Target
Tyrosine--tRNA ligase, cytoplasmic
Ligand
BDBM50104314
Substrate
n/a
Meas. Tech.
ChEBML_211023
IC50
>3000±n/a nM
Citation
 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383. Bioorg Med Chem Lett 11:2499-502 (2001) [PubMed]  Article 
Target
Name:
Tyrosine--tRNA ligase, cytoplasmic
Synonyms:
SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1
Type:
PROTEIN
Mol. Mass.:
59145.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_211030
Residue:
528
Sequence:
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
  
Inhibitor
Name:
BDBM50104314
Synonyms:
(S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-cyclohexyl-acetic acid methyl ester | CHEMBL309467
Type:
Small organic molecule
Emp. Form.:
C18H26N2O4
Mol. Mass.:
334.41
SMILES:
COC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: