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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50546048
Substrate
n/a
Meas. Tech.
ChEMBL_2013848 (CHEMBL4667426)
EC50
20±n/a nM
Citation
 Engers, DW; Melancon, BJ; Gregro, AR; Bertron, JL; Bollinger, SR; Felts, AS; Konkol, LC; Wood, MR; Bollinger, KA; Luscombe, VB; Rodriguez, AL; Jones, CK; Bubser, M; Yohn, SE; Wood, MW; Brandon, NJ; Dugan, ME; Niswender, CM; Conn, PJ; Bridges, TM; Lindsley, CW VU6005806/AZN-00016130, an advanced M Bioorg Med Chem Lett 29:1714-1718 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50546048
Synonyms:
CHEMBL4776981
Type:
Small organic molecule
Emp. Form.:
C17H13Cl2F3N6OS
Mol. Mass.:
477.291
SMILES:
Cc1c(Cl)nnc2sc(C(=O)NC3CN(C3)c3cc(ncc3Cl)C(F)(F)F)c(N)c12
Structure:
Search PDB for entries with ligand similarity: