Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50546056
Substrate
n/a
Meas. Tech.
ChEMBL_2013850 (CHEMBL4667428)
EC50
>5000±n/a nM
Citation
 Engers, DW; Melancon, BJ; Gregro, AR; Bertron, JL; Bollinger, SR; Felts, AS; Konkol, LC; Wood, MR; Bollinger, KA; Luscombe, VB; Rodriguez, AL; Jones, CK; Bubser, M; Yohn, SE; Wood, MW; Brandon, NJ; Dugan, ME; Niswender, CM; Conn, PJ; Bridges, TM; Lindsley, CW VU6005806/AZN-00016130, an advanced M Bioorg Med Chem Lett 29:1714-1718 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50546056
Synonyms:
CHEMBL4743571
Type:
Small organic molecule
Emp. Form.:
C18H18ClN7OS
Mol. Mass.:
415.9
SMILES:
Cc1c(Cl)nnc2sc(C(=O)NC3CN(C3)c3ccc(nn3)C3CC3)c(N)c12
Structure:
Search PDB for entries with ligand similarity: