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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50106486
Substrate
n/a
Meas. Tech.
ChEMBL_139390 (CHEMBL747003)
Ki
183±n/a nM
Citation
 Melchiorre, C; Bolognesi, ML; Budriesi, R; Ghelardini, C; Chiarini, A; Minarini, A; Rosini, M; Tumiatti, V; Wade, EJ Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators. J Med Chem 44:4035-8 (2001) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50106486
Synonyms:
1,8-Bis-[1'-(2-methoxy-benzyl)-[4,4']bipiperidinyl-1-yl]-octane-1,8-dione | CHEMBL130835
Type:
Small organic molecule
Emp. Form.:
C44H66N4O4
Mol. Mass.:
715.0192
SMILES:
COc1ccccc1CN1CCC(CC1)C1CCN(CC1)C(=O)CCCCCCC(=O)N1CCC(CC1)C1CCN(Cc2ccccc2OC)CC1
Structure:
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